I think the A380 will be extended and will get a new engine option.
By then, the A380 will have been in production for a long time and, with general technological advances, will need to be upgraded to remain attractive to the marketplace, in exactly the same way as any aircraft programme has in the last fifty years.
True, the CEO was stupid to say what he did but to criticise the A380 programme for possibly heading for an upgrade now is no different, and no less unfair, than criticising Boeing would have been for turning the B747-100 into the 200/300 back in the day.