I would see if your monitor has a setting to display upside down, if so I would see if your monitor can conveniently be mounted upside down.

If your monitor doesn’t have the settings to display upside down then perhaps there is an add-on program that does

There was a gag program, that people used to use as a gag that would make your monitor display upside down. If you executed the program again and would display upright. This gag program would often be detected by antivirus software as malicious; even though it was just supposedly a prank program. I personally wouldn’t load anything that my antivirus programs flags; but perhaps you are more desperate and more software savvy.

I did a quick search and the only thing I was able to find was a game by the same name.
Topsyturvy.exe

I have turned many computers and TV CRTs upside down to compensate for burn in and to allow more life to be milked out of burned in monitors. Some of the legacy computers and TV CRTs were designed to be flipped. I don’t know if the same is true for the new flat-panel displays.

However as I said some of the new flat-panel displays are designed so the entire monitor can be flipped.

The next short-term fix is slightly expensive: replace the monitor.

However it sounds like the only long-term solution is very expensive: replace the wife. 😉 However considering the channel that she is watching, it might be well worth it in savings. 😉