Most places I read say there won’t be substantial increases to weapons. Same VLS, same main gun.

Main change is to the radars. The S band AESA, AMDR replacing SPY-1, and a new X band AMDR component, that will be fulfilled by SPQ-9B on initial ships, and by a true fixed face X band radar on later flight iii ships. They also replace 3×3 megawatt electric plants with 3×4 megawatt plants.
There will also be less notable changes inside of course. Sonar upgrades, internal electronics.

I think recently the USN said it was starting to look into a new destroyer called “future surface combatant,” to come into service in the 2030s. But that is obviously ages away. Who knows what new tech will see itself on that ship by then.

In the near term to mid term it looks like flight iii burke will be the main mass production surfaces combatant of the USN.