I’ve been to Prague seven times and I love it. I used to have family over there so I was a frequent visitor to Ruznye, but that was before the low cost boom, when I went I flew on BA, Excalibur, GB Airways, bmi and CSA. It’s a great place and I hope to go back in the summer.
As for Ryanair, well according to Michael O’leary they aren’t interested in entering the Eastern European market, however it has been rumored that Ryanair plan to fly into the Czech Republic into a former military base about 30 Miles North East of Prague.